The Binding of Isaac is a 2D action in which the player controls Isaac or one of five other unlockable characters as he explores the dungeons located in his mother's basement.
On each floor of the basement dungeon, the player must fight monsters in a room before he can continue onto the next room. Along the way, the player can collect money to buy equipment from shopkeepers, keys to unlock special treasure rooms, and new weapons and power-ups to strength his chances against the enemies. Each floor of the dungeon includes a boss which the player must defeat before continuing onto the next level.
On each floor of the basement dungeon, the player must fight monsters in a room before he can continue onto the next room. Along the way, the player can collect money to buy equipment from shopkeepers, keys to unlock special treasure rooms, and new weapons and power-ups to strength his chances against the enemies. Each floor of the dungeon includes a boss which the player must defeat before continuing onto the next level.